Pat the salmon fillets dry.
Season both sides with olive oil, paprika, garlic powder, onion powder, Italian seasoning, salt, and black pepper.
Bring a large pot of salted water to a boil.
Cook the penne pasta until al dente.
Reserve 1/2 cup of pasta water before draining the pasta.
Heat a large skillet over medium high heat.
Cook the salmon for 4 to 5 minutes on the first side and 2 to 3 minutes on the second side until browned and cooked through.
Remove the salmon from the skillet and allow it to rest.
Reduce the heat to medium.
Add butter and mushrooms to the skillet.
Cook until the mushrooms have softened.
Add garlic and cook for 30 seconds.
Pour in the heavy cream and bring to a light simmer.
Add Parmesan cheese and black pepper.
Stir until the sauce is smooth and creamy.
Adjust the consistency with reserved pasta water if needed.
Add the cooked penne and toss until evenly coated in the Alfredo sauce.
Plate the creamy penne Alfredo.
Top with Monterey style salmon.
Finish with chopped parsley and lemon slices before serving.